September 1, 1998Journal of Medical Virology
Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM
Population
12 children with sequentially collected serum specimens during the prediabetic period, from a prospective…
Design
Cohort
Authors
Discussion
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Overview
Multiple enterovirus serotypes temporally linked to IDDM onset in children; observational data leaves open causality and requires prospective validation.
Structured PICO
P
Population
12 children with sequentially collected serum specimens during the prediabetic period, from a prospective multicentre study of siblings of index cases with insulin-dependent diabetes mellitus.
O
Outcome
Association of specific enterovirus serotypes (coxsackievirus A9, B1-6, echovirus 1, 11) with increases in islet cell antibodies, insulin autoantibodies, GAD antibodies, or clinical onset of IDDM.
Several different enterovirus serotypes, not just coxsackie B4, may play a role in the pathogenesis of insulin-dependent diabetes mellitus.
Cite This Study
Roivainen et al. (1998) studied this question.