November 1, 1995The Journal of Infectious Diseases

Serologic Evidence of an Association between Enteroviruses and the Onset of Type 1 Diabetes Mellitus

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Why the study?

Is enterovirus infection associated with the onset of Type 1 Diabetes Mellitus in children?

Structured PICO

Is enterovirus infection associated with the onset of Type 1 Diabetes Mellitus in children?

Population

248 children ≤ 18 years of age, comprising 128 patients with new-onset insulin-dependent diabetes mellitus (IDDM) and 120 control-patients frequency-matched for age, sex, and date of bleed.

Intervention

IgM positivity against 14 enterovirus serotypes (coxsackieviruses B1-B6 and A9, echoviruses 4, 6, 9, 11, 30, and 34, and enterovirus 71)

Comparator

Control patients without IDDM

Outcome

IgM positivity for enterovirus serotypessurrogate

The study provides serologic evidence supporting an association between enterovirus infection and the onset of Type 1 Diabetes Mellitus in older children.

Discussion

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Implication

Enterovirus IgM positivity associated with T1DM onset in adolescents; hypothesis-generating and requires prospective validation before any clinical implications.

Cite This Study

Helfand et al. (1995) studied this question.

synapsesocial.com/papers/6a6f8543439bab0cabc2d35d https://doi.org/10.1093/infdis/172.5.1206

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Implication

Enterovirus IgM positivity associated with T1DM onset in adolescents; hypothesis-generating and requires prospective validation before any clinical implications.

Serologic Evidence of an Association between Enteroviruses and the Onset of Type 1 Diabetes Mellitus

Structured PICO

Discussion

Implication

Cite This Study

Serologic Evidence of an Association between Enteroviruses and the Onset of Type 1 Diabetes Mellitus

Structured PICO

Discussion

Implication

Cite This Study

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