Why the study?
Does Sabin type 1 live oral poliovirus vaccine reduce the morbidity of poliomyelitis in children when administered during an epidemic?
Population
292,316 children, 3 months to 6 years of age, residing in study areas in Hokkaido, Fukuoka, and Kumamoto…
Comparison
Sabin type 1 live oral poliovirus vaccine vs Unvaccinated children in the same study areas
Design
Cohort
Follow-up
Up to 6 months
Authors
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May support Sabin vaccine use in polio epidemics; leaves open confirmation in larger studies before any practice change.
Does Sabin type 1 live oral poliovirus vaccine reduce the morbidity of poliomyelitis in children when administered during an epidemic?
Administration of the Sabin type 1 live oral poliovirus vaccine during an epidemic was associated with a sharp decline in polio morbidity, suggesting it can interfere with the progress of an epidemic.
EPIDEMIOLOGY SUBCOMMITTEE (1967) studied this question.
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