Population
15 poliovirus strains recovered from stool of vaccinees and contacts, tested in cynomolgus monkeys
Comparison
Intracerebral and intraspinal inoculation of… vs Original Sabin live oral poliovaccine
Design
Preclinical
Authors
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May warrant enhanced OPV strain surveillance; leaves open clinical relevance and need for human studies.
Poliovirus strains recovered from vaccinees showed increased neurovirulence in monkey models, particularly type 3 strains, highlighting potential risks of live attenuated vaccines.
Egashira et al. (1967) studied this question.
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