Why the study?
Do live orally administered poliovirus vaccine strains undergo genetic changes and exhibit neurovirulence after human passage?
Do live orally administered poliovirus vaccine strains undergo genetic changes and exhibit neurovirulence after human passage?
Live oral poliovirus vaccine strains exhibit genetic instability and increased neurovirulence after human passage, warranting caution.
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May warrant genetic surveillance of oral polio vaccines; leaves open effects of enteroviral interference on modern schedules.
Joseph L. Melnick (1959) studied this question.
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