March 3, 2016PLoS PathogensOpen Access

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

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Population

EV71 particles and 6-day-old mouse model of lethal EV71 infection

Comparison

Monoclonal antibody D5, administered as a single… vs PBS or irrelevant monoclonal antibody 3F5

Design

Preclinical

Follow-up

14 days (in mouse model)

Authors

XYXiaohua YeEnergetiq Technology (United States)ZKZhiqiang KuWestlake University TZTeng ZuoBroad Institute

Discussion

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Implication

May support mAb D5 development for EV71; leaves open human translation and trials.

Structured PICO

Population

EV71 particles (mature virion, procapsid, VLP) and 6-day-old mouse model of lethal EV71 infection (EV71/MAV-W strain)

Intervention

Monoclonal antibody D5 (intact IgG or Fab fragment), administered as a single dose (10 μg/g body weight) in the mouse model

Comparator

PBS or irrelevant monoclonal antibody 3F5

Outcome

Cryo-EM structure of EV71-D5 complex and survival in a lethal mouse model of EV71 infectionsurrogate

The broadly neutralizing monoclonal antibody D5 protects against lethal EV71 infection in mice by bivalently binding the highly conserved VP1 GH-loop, providing a structural basis for potential anti-EV71 therapeutics.

Cite This Study

Ye et al. (2016) studied this question.

synapsesocial.com/papers/6a9075701f441c9f75c7a45d https://doi.org/10.1371/journal.ppat.1005454

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Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider