August 15, 2013Journal of VirologyOpen Access

A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody

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Population

Enterovirus 71 (EV71) and monoclonal antibody MA28-7 Fab fragment complex

Design

Preclinical

Authors

HLHyunwook LeeUniversity of Minnesota JCJavier O. CifuenteUniversity of the Basque Country RARobert E. AshleyPennsylvania State University

Discussion

Member takes

Implication

Elucidates EV71 neutralization epitope; leaves open translation to vaccines or therapeutics.

Structured PICO

Population

Enterovirus 71 (EV71) and monoclonal antibody MA28-7 Fab fragment complex

Intervention

Cryo-electron microscopy

Outcome

Identification of the strain-specific epitope of EV71 and structural characterization of the complexsurrogate

Cryo-EM structural analysis identifies the strain-specific epitope of EV71 bound to neutralizing antibody MA28-7, providing insights into potential neutralization mechanisms.

Cite This Study

Lee et al. (2013) studied this question.

synapsesocial.com/papers/6a83a4cd6de9cd8ef3ee739f https://doi.org/10.1128/jvi.01926-13

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A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider