February 24, 2012Virology JournalOpen Access

Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein

View Full Paper

Ask AI

Bookmark

Population

Mice immunized with the EV71-B5 strain and various enterovirus strains

Design

Preclinical

Authors

TKTanja K. KienerTemasek Life Sciences Laboratory QJQiang JiaShandong University of Traditional Chinese Medicine XLXiao Fang LimDuke-NUS Medical School

Discussion

Member takes

Implication

May support EV71-specific diagnostics; leaves open clinical translation from animal data alone.

Structured PICO

Population

Mice immunized with the EV71-B5 strain and various enterovirus strains (EV71 subgenogroups, Coxsackieviruses 4, 6, 10, and 16)

Intervention

Monoclonal antibody 7C7

Outcome

Epitope mapping and specificity of monoclonal antibody 7C7 for EV71 VP2 proteinsurrogate

Monoclonal antibody 7C7 specifically recognizes a linear epitope on the EV71 VP2 protein and can differentiate Enterovirus 71 from Coxsackievirus 16, providing a potential diagnostic tool.

Cite This Study

Kiener et al. (2012) studied this question.

synapsesocial.com/papers/6a85232fff13e6e4e743d2db https://doi.org/10.1186/1743-422x-9-55

View Full Paper

Ask AI

Bookmark

Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider