Key result
Human IgM epitopes were mainly mapped to VP2 and VP3 during acute EV71 infection, while the only IgG epitope identified was located on VP1 during the recovery phase.
Population
Sera from EV71-infected children in acute or recovery phase, and sera from rabbits immunized with…
Design
Preclinical
Authors
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May guide EV71 vaccine and diagnostic development; leaves open clinical translation from animal epitope data.
Human IgM epitopes against EV71 are mainly mapped to VP2 and VP3 during acute infection, whereas the IgG response in the recovery phase is localized to VP1, which may inform vaccine evaluation and diagnostic development.
Gao et al. (2012) studied Enterovirus 71 (EV71) infection (n=23). EV71 infection vs. Healthy controls was evaluated on Identification of human anti-EV71 IgM and IgG epitopes. Human IgM epitopes were mainly mapped to VP2 and VP3 during acute EV71 infection, while the only IgG epitope identified was located on VP1 during the recovery phase.
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