Key result
Recombinant VP1 antigen effectively detected IgM in acute and IgG in past enterovirus 71 infections without cross-reacting with coxsackie virus 16 antibodies.
Why the study?
Is recombinant VP1 protein an effective and specific antigen for the serodiagnosis of enterovirus 71 infection?
Population
Sera from patients with enterovirus 71 infection and sera containing coxsackie virus 16 (CA16) antibodies
Comparison
Recombinant enterovirus 71 capsid protein VP1… vs Reference PCR and neutralization assays
Design
Preclinical
Authors
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Supports VP1 for EV71 serodiagnosis development; leaves open human validation before clinical adoption.
Is recombinant VP1 protein an effective and specific antigen for the serodiagnosis of enterovirus 71 infection?
Recombinant VP1 protein is an effective and specific antigen for determining the different phases of enterovirus 71 infection without cross-reactivity to CA16.
Shih et al. (2000) studied Enterovirus 71 infection. Recombinant VP1 antigen vs. Reference PCR and neutralization assays was evaluated on Detection of IgG and IgM antibodies. Recombinant VP1 antigen effectively detected IgM in acute and IgG in past enterovirus 71 infections without cross-reacting with coxsackie virus 16 antibodies.
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