Key result
Rabbits immunized with purified recombinant NPt-VP(1-100) and NPfl-VP(1-100) proteins exhibited a strong immune response against the complete enterovirus 71 VP1 protein.
Population
Rabbits and Escherichia coli (for protein expression)
Design
Preclinical
Authors
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Hypothesis-generating for EV71 VP1 immunogenicity in rabbits; leaves open human translation and clinical utility.
Recombinant newcastle disease virus capsids displaying enterovirus 71 VP1 fragments can induce a strong immune response in rabbits, suggesting potential utility as immunological reagents.
Sivasamugham et al. (2006) studied Enterovirus 71. Recombinant NPt-VP(1-100) and NPfl-VP(1-100) proteins was evaluated on Immune response against complete VP1 protein. Rabbits immunized with purified recombinant NPt-VP(1-100) and NPfl-VP(1-100) proteins exhibited a strong immune response against the complete enterovirus 71 VP1 protein.
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