Primary Hyperlipidemias and Their Management

Article1 October 1963Primary Hyperlipidemias and Their ManagementPETER T. KUO, M.D., D.SC., F.A.C.P., DAVID R. BASSETT, M.D.PETER T. KUO, M.D., D.SC., F.A.C.P., DAVID R. BASSETT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-4-495 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinically encountered hyperlipidemic states differ from one another in the type of lipid abnormalities observed in the plasma and tissues and the manner in which these abnormalities are produced. The primary hyperlipidemias are states in which the plasma lipid abnormalities are frequently related to a genetic defect, in contrast to hyperlipidemias secondary to specific metabolic disorders. The importance of these primary hyperlipidemias in the development of atherosclerosis has been well recognized (1-4).In differentiating the various types of hyperlipidemia, extensive investigations have been made of the serum lipoproteins and serum lipids of hyperlipidemic patients (5-10). Efforts have also been...References1. ADLERSBERGSCHAEFER CLH: The interplay of hereditary and environment in the regulation of circulating lipids and in atherogenesis. Amer. J. Med. 26: 1, 1959. CrossrefMedlineGoogle Scholar2. EPSTEINBLOCKHANDFRANCIS FHWDEAT: Familial hypercholesterolemia, xanthomatosis and coronary artery disease. Ibid., 39. Google Scholar3. SOFFERMURRAY AM: Relationship of essential hyperlipemia to premature atherosclerosis. Circulation 10: 611, 1954. Google Scholar4. FREDRICKSON DS: Essential familial hyperlipidemia, in The Metabolic Basis of Inherited Disease, McGraw-Hill Book Co., Inc., New York, 1960, p. 489. Google Scholar5. 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Effects of dairy foods, phospholipid, coconut oil and alcohol. Arch. Intern. Med. (Chicago) 102: 173, 1958. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER T. KUO, M.D., D.SC., F.A.C.P.; DAVID R. BASSETT, M.D.Affiliations: Philadelphia, PennsylvaniaThis work was carried out during Dr. Kuo's tenure as Research Career Development Awardee and was supported by grant AM-K-3-HE-3392 from the National Institute of Arthritis and Metabolic Disease, National Institutes of Health, United States Public Health Service, Bethesda, Maryland. Support was also received in grants from the American Heart Association, grant H-5541 from the National Heart Institute, and grant OG-16 from the Division of General Medical Sciences, National Institutes of Health, United States Public Health Service, Bethesda, Maryland. Dr. Bassett is a postdoctoral fellow of the National Heart Institute, National Institutes of Health, Bethesda, Maryland.Presented in part at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April, 1962.Requests for reprints should be addressed to Peter T. Kuo, M.D., Hospital of the University of Pennsylvania, Edward B. Robinette Foundation, Cardiovascular Section, 3400 Spruce Street, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFatty acid composition of adipose tissue in humans. 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BASSETT, M.D.Serum lipid changes following myocardial infarctionLipolytic Activity of Post-Heparin Plasma in Hyperlipemia and Hypolipemia 1 October 1963Volume 59, Issue 4Page: 495-507KeywordsAtherosclerosisBlood plasmaCareers in researchHeartHyperlipidemiaLipidsMedical servicesMetabolic disordersPrevention, policy, and public healthSodium ePublished: 1 December 2008 Issue Published: 1 October 1963 PDF downloadLoading ...