Certain monoclonal antibodies can irreversibly inactivate poliovirus specifically at fever temperatures (39°C).
May enable fever-targeted antiviral mAbs; hypothesis-generating in animal models and requires human validation before any clinical consideration.
Three of thirty-six monoclonal antibodies were found to cause irreversible inactivation of type 1 poliovirus at 39 degrees C but not at 37 degrees C. Neutralization at 37 degrees C depended on aggregation and was reversible by acid-induced deaggregation; at 39 degrees C, the virions (N antigenic, 160S) were disrupted to empty capsids (H antigenic, 100S), and neutralization was irreversible. The rate of antibody-dependent conversion of N to H antigen increased steeply between 37 and 39 degrees C.
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Delaet et al. (1993) studied this question.
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