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June 1, 1996Microcirculation

Regulation of the Gene‐Encoding Angiotensin II Receptor in Vascular Tissue

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Population

Preclinical models subjected to Ang II infusion or hypertension induced by reduced renal mass plus high salt…

Design

Preclinical

Authors

DWDonna H. WangMichigan State UniversityYDYong DuJiangnan University

Discussion

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Implication

Tissue-specific AT1 regulation is hypothesis-generating in this model; leaves open relevance to human hypertension therapy.

Structured PICO

P
Population
Preclinical models (aorta, resistant arteries, and heart tissue) subjected to Ang II infusion or hypertension induced by reduced renal mass plus high salt intake
I
Intervention
Angiotensin II infusion (25 ng.kg.min-1) or captopril
O
Outcome
Expression of the gene-encoding Ang II type 1 (AT1) receptor mRNAsurrogate

The regulation of AT1 gene expression appears to be pressure-dependent in the heart but Ang II-dependent in the aorta.

Cite This Study

Wang et al. (1996) studied this question.

synapsesocial.com/papers/6a907d134aebf474cb342603https://doi.org/10.3109/10739689609148295
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys1991 · 68 citations
  2. 2Autoradiographic characterization of angiotensin receptor subtypes in fetal and adult human kidney1992 · 97 citations
  3. 3Binding Characteristics and Vascular Effects of Various Angiotensin II Antagonists1990 · 60 citations
  4. 4Longitudinal effect of captopril on aortic and arteriolar development in normotensive rats1991 · 26 citations
  5. 5Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis.1994 · 169 citations