January 1, 1985Journal of Cardiovascular Pharmacology
Reflex Cardiovascular Regulation in Humans
Population
Humans (including normotensive subjects, and those in states of aging, exercise, and hypertension)
Design
Review
Authors
Discussion
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Implication
Supports selective baroreflex assessment in aging and hypertension; leaves open pressure-specific mechanisms for future trials.
Key Points
- To examine carotid baroreceptor reflex regulation of the human cardiovascular system under various physiological and pathophysiological conditions, and compare arterial and cardiopulmonary receptor influences on regional circulation and renin secretion.
- Reviewed physiological findings obtained via the variable-pressure neck-chamber technique to evaluate carotid baroreflex function in humans.
- Analyzed baroreceptor responses during aging, physical exercise, and hypertension, as well as reflex effects on regional vascular beds and plasma renin activity relative to cardiopulmonary receptor inputs.
- The carotid baroreflex set-point in normotensive subjects is positioned eccentrically near saturation, buffering blood pressure reductions more effectively than blood pressure elevations.
- Impairments observed during aging, exercise, and hypertension compromise arterial baroreceptor control of heart rate, but arterial blood pressure control remains preserved.
- Cardiopulmonary receptors exert primary control over arterial baroreceptors in modulating plasma renin activity to regulate blood volume.
Structured PICO
P
Population
Humans (including normotensive subjects, and those in states of aging, exercise, and hypertension)
This review clarifies that while baroreceptor control of heart rate is impaired in aging and hypertension, its control of arterial pressure is maintained, and cardiopulmonary receptors are the primary reflex modulators of plasma-renin activity.
Cite This Study
Mancia et al. (1985) studied this question.