New pressure wave reflections generated at the reconstructed site after aortic arch repair may contribute to the development of early-onset cardiovascular diseases in patients with aortic coarctation.
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Wave reflection from the repair site may drive early aortic augmentation post-arch repair; hypothesis-generating for targeted interventions.
BACKGROUND: In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop. SUMMARY: We studied the pressure waveform in patients after aortic arch repair focusing on a pressure wave reflection. In patients after aortic arch repair, the repaired portion generates a new reflected pressure wave. As a result, the newly generated pressure wave causes aortic pressure augmentation, loss of pressure amplification, and left ventricular hypertrophy with fibrosis. Balloon dilatation of the aortic arch may also generate a new pressure wave reflection. KEY MESSAGES: In patients with aortic coarctation after aortic arch repair, the reconstructed site generates a new pressure wave reflection. This could be one of the causes of their future cardiovascular diseases.
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Tomoaki Murakami (2017) studied this question.
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