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December 29, 2012Diabetes CareOpen Access

Impact of Diabetes on Long-Term Outcome After Primary Angioplasty

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Why the study?

Does diabetes worsen long-term outcomes in STEMI patients undergoing primary angioplasty with bare metal or drug-eluting stents?

Population

6,298 ST-segment elevation myocardial infarction patients undergoing primary angioplasty, pooled from 11…

Comparison

Presence of diabetes mellitus vs Absence of diabetes mellitus

Design

Meta-analysis

Follow-up

1,201 ± 441 days

Authors

GLGiuseppe De LucaInterventional CardiologyMDMaurits T. DirksenNoordwest ZiekenhuisgroepCSChristian SpauldingInterventional / Structural Cardiology

Discussion

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Implication

Diabetes heightens long-term mortality and ischemic risks after primary angioplasty in STEMI; confirms diabetes as an independent predictor despite contemporary stents.

Structured PICO

Does diabetes worsen long-term outcomes in STEMI patients undergoing primary angioplasty with bare metal or drug-eluting stents?

P
Population
6,298 ST-segment elevation myocardial infarction (STEMI) patients undergoing primary angioplasty, pooled from 11 randomized trials comparing DES with BMS (DESERT database).
I
Intervention
Presence of diabetes mellitus
C
Comparator
Absence of diabetes mellitus
O
Outcome
Long-term rates of death, reinfarction, stent thrombosis, and target vessel revascularization (TVR)hard clinical

Diabetes remains a strong independent predictor of long-term mortality, reinfarction, and stent thrombosis in STEMI patients undergoing primary angioplasty, though DES use mitigates the excess risk of target vessel revascularization.

Cite This Study

Luca et al. (2012) studied this question.

synapsesocial.com/papers/6a90809933cf5c591c0d647ahttps://doi.org/10.2337/dc12-1507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of diabetics receiving bare‐metal stents versus drug‐eluting stents2010 · 6 citations
  2. 2Outcomes after primary coronary intervention with drug-eluting stent implantation in diabetic patients with acute ST elevation myocardial infarction2007 · 15 citations
  3. 3A comparative analysis of major clinical outcomes using drug‐eluting stents versus bare metal stents in diabetic versus nondiabetic patients2011 · 16 citations
  4. 4Efficacy of Drug-Eluting Stents in Diabetic Patients Admitted with ST-Elevation Myocardial Infarctions Treated with Primary Percutaneous Coronary Intervention2021 · 5 citations
  5. 5Influence of Diabetes Mellitus on Outcome in the Era of Primary Stenting for Acute Myocardial Infarction.2002 · 22 citations