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August 1, 1994Journal of Clinical MicrobiologyOpen Access

Astrovirus as a cause of gastroenteritis in Japan

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Why the study?

Is enzyme immunoassay more sensitive than electron microscopy for detecting astrovirus in stool specimens from gastroenteritis patients?

Population

Stool specimens from outbreaks and sporadic cases of gastroenteritis collected between 1982 and 1992 in six…

Comparison

Enzyme immunoassay (EIA) screening for astrovirus vs Electron microscopy (EM)

Design

Cross-sectional

Authors

EUEtsuko UTAGAWANational Institute of Infectious DiseasesSNShuichi NISHIZAWANational Institute of Infectious DiseasesSSSeiji SekineThe Nisshin OilliO Group (Japan)

Discussion

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Implication

Supports astrovirus testing in unexplained gastroenteritis; leaves open whether EIA should replace EM in routine use.

Structured PICO

Is enzyme immunoassay more sensitive than electron microscopy for detecting astrovirus in stool specimens from gastroenteritis patients?

P
Population
Stool specimens from outbreaks and sporadic cases of gastroenteritis collected between 1982 and 1992 in six prefectural public health institutes in Japan.
I
Intervention
Enzyme immunoassay (EIA) screening for astrovirus
C
Comparator
Electron microscopy (EM)
O
Outcome
Detection of astrovirus

Astrovirus is a more common cause of childhood gastroenteritis in Japan than previously appreciated, and EIA is a sensitive detection method.

Limitations

  • Inadequate storage conditions (long-term storage, repeated freezings and thawings) may have caused false negatives in EIA for older specimens.

Cite This Study

UTAGAWA et al. (1994) studied this question.

synapsesocial.com/papers/6a9080d9fdaee66aea84112dhttps://doi.org/10.1128/jcm.32.8.1841-1845.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis.1993 · 287 citations
  2. 2Subgenomic RNA sequence of human astrovirus supports classification of Astroviridae as a new family of RNA viruses1993 · 196 citations
  3. 3Astrovirus-associated diarrhea among Guatemalan ambulatory rural children1992 · 121 citations
  4. 4Serial Propagation of Astrovirus in Tissue Culture with the Aid of Trypsin1981 · 145 citations
  5. 5Astrovirus and Adenovirus Associated with Diarrhea in Children in Day Care Settings1991 · 105 citations