Why the study?
Does collagen or aspirin affect cyclic GMP concentration in human blood platelets?
Does collagen or aspirin affect cyclic GMP concentration in human blood platelets?
Collagen increases and aspirin decreases cyclic GMP in human platelets, suggesting a role for cyclic GMP in the platelet release reaction.
May implicate cGMP in platelet release; hypothesis-generating for human studies and should not change practice.
A method is described for isolating cyclic [(3)H]GMP from platelets preincubated with [(3)H]guanine. Collagen increased and aspirin decreased the cyclic [(3)H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.
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Haslam et al. (1974) studied this question.
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