April 1, 2002Journal of Biological ChemistryOpen Access

The Slippage of the Ca2+ Pump and Its Control by Anions and Curcumin in Skeletal and Cardiac Sarcoplasmic Reticulum

View Full Paper

Ask AI

Bookmark

Population

Isolated skeletal and cardiac sarcoplasmic reticulum (SR) vesicles

Design

Preclinical

Authors

CSCarlota SumbillaUniversity of Maryland, Baltimore DLDavid E. LewisUniversity of Wisconsin–Eau Claire THTina Hammerschmidt

Discussion

Member takes

Implication

Low-dose curcumin may enhance SR Ca2+ efficiency in vitro; leaves open translation to in vivo cardiac models or therapy.

Structured PICO

Population

Isolated skeletal and cardiac sarcoplasmic reticulum (SR) vesicles

Intervention

Curcumin (1-5 micromolar and 5-30 micromolar) and anions (phosphate or oxalate)

Outcome

Ca2+ transport efficiency, coupling ratios, and ATPase activitysurrogate

Low concentrations of curcumin improve Ca2+ transport efficiency in cardiac and skeletal sarcoplasmic reticulum, highlighting a potential mechanism to correct defective Ca2+ homeostasis.

Cite This Study

Sumbilla et al. (2002) studied this question.

synapsesocial.com/papers/6a90853bc7b7d4543f89f570 https://doi.org/10.1074/jbc.m111155200

View Full Paper

Ask AI

Bookmark