ChemInform Abstract: 2(1H)‐Quinolinones with Cardiac Stimulant Activity. Part 3. Synthesis and Biological Properties of 6‐Imidazol‐1‐yl Derivatives.

December 5, 1989ChemInform

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Key Points

Synthesize a series of novel 6-imidazol-1-yl-2(1H)-quinolinone derivatives to investigate their potential cardiac stimulant properties.
Synthesized 23 substituted imidazoylquinolinone derivatives according to a multi-step reaction scheme.
Prepared target compounds including designated analogs (II), (IV), (VI)–(VIII), (X), (XII), (XIV), and (XVI).
Successfully prepared 23 distinct substituted imidazoylquinolinone chemical derivatives via the outlined synthetic pathways.
Established chemical routes for introducing 6-imidazol-1-yl substituents onto the 2(1H)-quinolinone core framework.

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Describes the synthesis of 23 substituted 6-imidazol-1-yl-2(1H)-quinolinone derivatives, suggesting their potential utility as cardiac stimulants.

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Bell et al. (1989) studied this question.

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