Population
Cultured mammalian skeletal muscle cells and zebrafish embryos
Comparison
Aciculin (PGM5) knockdown/depletion vs Control (implied wild-type/normal expression)
Design
Preclinical
Authors
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Preclinical knockdown phenotypes do not yet inform patient care; leaves open aciculin as a therapeutic target in myofibrillar myopathies.
Aciculin interacts with FLNc and Xin and plays an essential role in myofibril formation, maintenance, and remodeling.
Molt et al. (2014) studied this question.
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