The Blood Pressure Reducing Property of Extracts of Kidneys in Hypertensive Patients and Animals

Article1 September 1941THE BLOOD PRESSURE REDUCING PROPERTY OF EXTRACTS OF KIDNEYS IN HYPERTENSIVE PATIENTS AND ANIMALSIRVINE H. PAGE, M.D., O. M. HELMER, Ph.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., W. D. GAMBILL, M.D., R. D. TAYLOR, M.D.IRVINE H. PAGE, M.D., O. M. HELMER, Ph.D., K. G. KOHLSTAEDT, M.D., G. F. KEMPF, M.D., W. D. GAMBILL, M.D., R. D. TAYLOR, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt1. Tigerstedt and Bergmann1 demonstrated that bilateral nephrectomy increases the rise in arterial pressure occurring in anesthetized animals when extracts of kidney containing renin are injected into them. This observation was confirmed by Merrill, Williams and Harrison,2 and by Fasciolo, Houssay and Taquini3 who suggested that the increased sensitivity might be due to loss of an anti-pressor substance. Similar increase in sensitivity was observed by Page and Helmer4 when angiotonin was administered instead of renin. Angiotonin is the pressor substance resulting from interaction of renin and renin-activator.5Nephrectomy therefore appears to remove the source of some substance which opposes the...Bibliography1. TIGERSTEDTBERGMANN RPG: Niere und Kreislauf, Skand. Arch. f. Physiol., 1898, viii, 223. CrossrefGoogle Scholar2. MERRILLWILLIAMSHARRISON ARHTR: The effects of a pressor substance obtained from the kidneys on the renal circulation of rats and dogs, Am. Jr. Med. Sci., 1938, cxcvi, 240. CrossrefGoogle Scholar3. FASCIOLOHOUSSAYTAQUINI JCBAAC: The blood pressure raising secretion of the ischemic kidney, Jr. Physiol., 1938, xciv, 281. CrossrefGoogle Scholar4. PAGEHELMER IHOM: Angiotonin-activator, renin and angiotonin inhibitor and the mechanism of angiotonin tachyphylaxis in normal, hypertensive and nephrectomized animals, Jr. Exper. Med., 1940, lxxi, 495. CrossrefGoogle Scholar5. 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Invest., 1934, xiii, 909. CrossrefGoogle Scholar28. PAGE IH: A clinical study of malignant hypertension, ANN. INT. MED., 1939, xii, 978. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Lecture given before the Third General Session of the American College of Physicians, April 22, 1941, Boston, Massachusetts.From the Lilly Laboratory for Clinical Research, Indianapolis City Hospital, Indianapolis, Indiana. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Enzymes and Essential HypertensionThe vasodepressor function of the kidney: prostaglandin E2 is not the principal vasodepressor lipid of the renal medullaThe Vasodepressor Function of the Kidney: Further Characterization of Medullipin and a Second Hormone Designated AngiolysinAssessment of the Kidney in Relation to Blood Pressure RegulationAntihypertensive functions of the kidney: Arthur C. Corcoran memorial lecture.Prostaglandins and the Renal Antihypertensive and Natriuretic Endocrine FunctionRenal Homeostasis and the Hypertensive State: A Unifying HypothesisThe Antihypertensive and Natriuretic Endocrine Function of the Kidney: Vascular and Metabolic Mechanisms of the Renal ProstaglandinsMECHANISMS, DIAGNOSIS AND TREATMENT OF HYPERTENSION OF RENAL VASCULAR ORIGIN*IRVINE H. PAGE, M.D., F.A.C.P., HARRIET P. DUSTAN, M.D., EUGENE F. POUTASSE, M.D.Herz und KreislaufDie Klinik und Chemie der Proteinasen des menschlichen und tierischen Organismus, ihre besondere Bedeutung in seinen Abwehrleistungen und in der klinischen DiagnostikVASOCONSTRICTORS IN THE COMMON COLDPENICILLIN IN RHEUMATIC FEVERRENAL EXTRACTS IN HYPERTENSIONThe Treatment of HypertensionArterial Hypertension 1 September 1941Volume 15, Issue 3Page: 347-389KeywordsBlood pressureClinical laboratoriesKidneysNephrectomyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1941 Copyright & PermissionsCopyright, 1941, by The American College of PhysiciansPDF downloadLoading ...