What question did this study set out to answer?

To develop a fast and flexible synthetic route for producing multivalent cluster glycosides by coupling glycosyl isothiocyanates to dendrimer amine cores.

September 20, 1996Angewandte Chemie International Edition in EnglishOpen Access

Glycocoating of Oligovalent Amines: Synthesis of Thiourea‐Bridged Cluster Glycosides from Glycosyl Isothiocyanates

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Authors

TLThisbe K. LindhorstKiel University CKChristoffer KieburgUniversität Hamburg

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Implication

Experimental study demonstrates gram-scale synthesis of thiourea-bridged cluster glycosides using dendrimers, indicating potential as cell-cell recognition antiadhesives.

Key Points

To develop a fast and flexible synthetic route for producing multivalent cluster glycosides by coupling glycosyl isothiocyanates to dendrimer amine cores.
Reacted glycosyl isothiocyanates with polyamidoamine dendrimer cores to generate thiourea linkages displaying clustered carbohydrate moieties.
Synthesized multivalent mannose-functionalized glycoconjugates using a scalable, gram-scale preparation protocol.
Successfully produced diverse thiourea-bridged cluster glycosides in high quantity via a rapid, modular chemical reaction.
Demonstrated that the resulting multivalent glycoconjugates function as effective antiadhesives in cell–cell recognition systems.

Cite This Study

Lindhorst et al. (1996) studied this question.

synapsesocial.com/papers/6a9097f06e7e048e0989dfc8 https://doi.org/10.1002/anie.199619531

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Implication

Experimental study demonstrates gram-scale synthesis of thiourea-bridged cluster glycosides using dendrimers, indicating potential as cell-cell recognition antiadhesives.

Glycocoating of Oligovalent Amines: Synthesis of Thiourea‐Bridged Cluster Glycosides from Glycosyl Isothiocyanates

Discussion

Member takes

Implication

Key Points

Cite This Study

Glycocoating of Oligovalent Amines: Synthesis of Thiourea‐Bridged Cluster Glycosides from Glycosyl Isothiocyanates

Discussion

Member takes

Implication

Key Points

Cite This Study

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