Why the study?
Does controlled hyperventilation increase blood lactate levels through peripheral release or altered splanchnic turn-over in piglets?
Population
20 piglets
Comparison
Controlled hyperventilation (mean PaCO2 3.5 kPa) vs Controlled normoventilation (mean PaCO2 5.4 kPa)
Design
Preclinical
Follow-up
120 minutes
Authors
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Hyperventilation may raise lactate via splanchnic mechanisms in piglets; hypothesis-generating, leaves open human relevance.
Does controlled hyperventilation increase blood lactate levels through peripheral release or altered splanchnic turn-over in piglets?
Hypocarbic hyperventilation increases blood lactate levels in piglets, likely due to altered splanchnic turn-over rather than increased peripheral release from skeletal muscles.
Karlsson et al. (1995) studied this question.
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