January 1, 1975Journal of Applied Physiology

Splanchnic hemodynamic response to passive hyperventilation

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Why the study?

Does passive hyperventilation with or without hypocapnia alter splanchnic hemodynamics in anesthetized dogs?

Population

Anesthetized, splenectomized, and paralyzed dogs

Comparison

Passive hyperventilation with respiratory… vs Passive hyperventilation with maintained…

Design

Preclinical

Authors

EJEric E. JohnsonThe Stern Cardiovascular Foundation

Discussion

Member takes

Implication

Does not support changes to hyperventilation practices; leaves open translation of splanchnic effects to humans.

Structured PICO

Does passive hyperventilation with or without hypocapnia alter splanchnic hemodynamics in anesthetized dogs?

Population

Anesthetized, splenectomized, and paralyzed dogs

Intervention

Passive hyperventilation (Vt 40 ml/kg) with respiratory alkalosis (mean Paco2 8 mmHg, mean pH 7.75)

Comparator

Passive hyperventilation (Vt 40 ml/kg) with maintained normocapnia (mean Paco2 37.6 mmHg, mean pH 7.41)

Outcome

Splanchnic hemodynamic responses (hepatic venous pressure, portal venous pressure, mesenteric vascular resistance, mesenteric Vo2, hepatic O2 uptake)surrogate

Passive hyperventilation alters splanchnic hemodynamics and reduces mesenteric oxygen consumption in dogs, regardless of whether normocapnia or hypocapnia is maintained.

Cite This Study

Eric E. Johnson (1975) studied this question.

synapsesocial.com/papers/6a9099362a22b8e8a92dba1b https://doi.org/10.1152/jappl.1975.38.1.156

View Full Paper

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Splanchnic hemodynamic response to passive hyperventilation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Splanchnic hemodynamic response to passive hyperventilation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider