Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1959The Journal of Clinical Endocrinology & Metabolism

Adrenocortical Response to Surgical Operations in Patients Treated With Corticosteroids or Corticotropin Prior to Surgery

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prior treatment with corticosteroids versus corticotropin affect the adrenocortical response to surgical operations?

Population

8 patients undergoing surgical operations, including 6 who had been receiving prolonged corticosteroid…

Design

Case_series

Authors

LMLeon J. MarksPalo Alto UniversityMDMichael J. DonovanSunshine Coast University HospitalFDFREDERICK J. DUNCANUnited States Department of Veterans Affairs

Discussion

Loading...

Member takes

Implication

May warrant preferring ACTH over corticosteroids preoperatively; case reports leave open need for controlled validation.

Structured PICO

Does prior treatment with corticosteroids versus corticotropin affect the adrenocortical response to surgical operations?

P
Population
8 patients undergoing surgical operations, including 6 who had been receiving prolonged corticosteroid therapy and 2 who had received long-acting ACTH preparations for ulcerative colitis.
I
Intervention
Preoperative intravenous ACTH and surgical operation
O
Outcome
Free plasma 17-OHCS response to preoperative intravenous ACTH and to surgical operationsurrogate

Patients treated with ACTH prior to surgery may maintain a normal pituitary-adrenal response to operation, unlike those on prolonged corticosteroid therapy.

Cite This Study

Marks et al. (1959) studied this question.

synapsesocial.com/papers/6a909bdfd0ab9f9d6889ec64https://doi.org/10.1210/jcem-19-11-1458
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACTH and Adrenocorticosteroids as Therapeutic Adjuncts in Infectious Diseases1957 · 55 citations
  2. 2EFFECTS OF EXOGENOUS ADRENOCORTICOTROPIC HORMONE (ACTH) UPON PITUITARY ACTH CONCENTRATION AFTER PROLONGED CORTISONE TREATMENT AND STRESS*1959 · 23 citations
  3. 3Determination, Recovery, Identification and Renal Clearance of Conjugated Adrenal Corticoids in Human Peripheral Blood.1955 · 59 citations
  4. 4A METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS IN BLOOD: 17-HYDROXYCORTICOSTERONE IN THE PERIPHERAL CIRCULATION*1952 · 454 citations