January 1, 1985The Journal of Japan Atherosclerosis SocietyOpen Access

Natural History of Coronary Arterial Disease; The Effects of Ca2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis

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Why the study?

Does anti-platelet therapy or calcium channel blockade prevent progression of coronary atherosclerosis in patients with effort angina?

Structured PICO

Does anti-platelet therapy or calcium channel blockade prevent progression of coronary atherosclerosis in patients with effort angina?

Population

323 patients with effort angina. Group I (n=96, medically treated, mean age 54.5), Group II (n=147, underwent CABG, mean age 54.1), and Group III (n=80, treated with PTCA, mean age 53.7).

Intervention

Anti-platelet therapy (trapidil 300 mg/day or dipyridamole 75 mg + aspirin 300 mg/day) or calcium channel blockade (nifedipine 40 mg/day) administered for a long period.

Comparator

Non-administered group (no anti-platelet or calcium channel blocker).

Outcome

Progression, non-progression, or regression of coronary atherosclerosis assessed by serial coronary angiography based on Kramer's criteria.surrogate

Long-term administration of antiplatelet agents or calcium channel blockers may prevent the angiographic progression of coronary atherosclerosis in patients with effort angina.

Limitations

Small sample size in long-term observation subgroups
Lack of direct histological proof of regression (relies on 2D angiographic changes)

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Antiplatelet or CCB use was associated with less angiographic progression in effort angina; hypothesis-generating and requires randomized confirmation before practice change.

Cite This Study

Yoshimasa Yabe (1985) studied this question.

synapsesocial.com/papers/6a909cd1e73a4c404fc95421 https://doi.org/10.5551/jat1973.13.4_793

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Implication

Antiplatelet or CCB use was associated with less angiographic progression in effort angina; hypothesis-generating and requires randomized confirmation before practice change.

Natural History of Coronary Arterial Disease; The Effects of Ca2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Natural History of Coronary Arterial Disease; The Effects of Ca2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider