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Population
mdx mice
Comparison
Reducing SLN expression vs control
Design
Animal experimental study
Answers are grounded in this paper and cite their sources.
May support SLN inhibition in dystrophin-deficient cardiomyopathy; hypothesis-generating with uncertain human translation.
First, reducing sarcopolin (SLN) expression improves sarco/endoplasmic reticulum Ca2+ uptake and intracellular Ca2+ handling and prevents cardiomyopathy in mdx mice. Second, reducing SLN expression prevents diastolic dysfunction and improves cardiac contractility in mdx mice Third, reducing SLN expression activates apelin-mediated cardioprotective signaling pathways in mdx heart.
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Mareedu et al. (2020) studied this question.
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