Why the study?
Does a single oral dose of cyclosporine increase systemic blood pressure or peripheral vascular resistance in healthy adults?
Population
16 healthy adult subjects
Comparison
Single oral dose of cyclosporine vs Vehicle (olive oil)
Design
RCT, randomized, double blind, placebo-controlled
Follow-up
2 hours
Authors
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No acute BP rise after single-dose cyclosporine in healthy adults; challenges immediate vasoconstriction and directs research to chronic mechanisms.
Does a single oral dose of cyclosporine increase systemic blood pressure or peripheral vascular resistance in healthy adults?
A single supratherapeutic oral dose of cyclosporine does not cause acute increases in blood pressure or peripheral vasoconstriction in healthy humans.
GALVAODELIMA et al. (1998) studied this question.
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