Why the study?
Does intravenous endotoxin (LPS) increase ocular vascular permeability in a rabbit model?
Population
New Zealand albino female rabbits weighing 1.8 to 2.2 kg
Comparison
Intravenous administration of Salmonella… vs Intravenous administration of 0.1 ml sterile…
Design
Preclinical
Follow-up
4 to 5 hours
Authors
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Highlights endotoxin models for ocular permeability research; leaves open human translation pending clinical studies.
Does intravenous endotoxin (LPS) increase ocular vascular permeability in a rabbit model?
Ocular albumin fluorophotometry is a sensitive, noninvasive technique demonstrating that extremely low doses of endotoxin induce non-linear, biphasic ocular vascular permeability changes in rabbits.
Cousins et al. (1982) studied this question.
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