March 1, 1988Muscle & Nerve

Transient weakness and altered membrane characteristic in recessive generalized myotonia (Becker)

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Population

5 unrelated patients with recessive generalized myotonia (Becker)

Design

Case_series

Authors

RRReinhardt RüdelUniversität Ulm KRK. RickerUniversity of Minnesota FLFrank Lehmann‐HornUniversität Ulm

Discussion

Member takes

Implication

May support tocainide for Becker myotonia symptoms; hypothesis-generating for ion channel-targeted therapies.

Structured PICO

Population

5 unrelated patients with recessive generalized myotonia (Becker)

Intervention

Tocainide (clinical observation) and in vitro electrophysiological testing of excised external intercostal muscle fibers

Outcome

Isometric force of arm and leg muscles, and in vitro membrane characteristics (resting potential, action potentials, current-voltage relationship)surrogate

The transient weakness and electrical instability in recessive generalized myotonia (Becker) can be explained by an N-shaped membrane characteristic driven by abnormal chloride and potassium conductances.

Cite This Study

Rüdel et al. (1988) studied this question.

synapsesocial.com/papers/6a90d1be01e1e58c2c70f47b https://doi.org/10.1002/mus.880110303

View Full Paper

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Bookmark

Transient weakness and altered membrane characteristic in recessive generalized myotonia (Becker)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transient weakness and altered membrane characteristic in recessive generalized myotonia (Becker)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider