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September 1, 1981Muscle & Nerve

Membrane defects in paramyotonia congenita with and without myotonia in a warm environment

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Population

Muscle biopsies from 3 patients with paramyotonia congenita and 3 control persons

Comparison

In vitro electrophysiological and contractile… vs Muscle biopsies from healthy control persons

Design

Preclinical

Authors

FLFrank Lehmann‐HornUniversität UlmRRReinhardt RüdelUniversität UlmRDReinhard DenglerMedizinische Hochschule Hannover

Discussion

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Implication

May link cold-induced depolarization to Na/Cl defects in paramyotonia; hypothesis-generating and requires human validation before clinical relevance.

Structured PICO

P
Population
Muscle biopsies from 3 patients with paramyotonia congenita and 3 control persons
I
Intervention
In vitro electrophysiological and contractile testing at 37°C and 27°C, including tetrodotoxin application
C
Comparator
Muscle biopsies from healthy control persons
O
Outcome
Sarcolemmal membrane parameters (resting potentials, conductances) and contractile propertiessurrogate

In vitro analysis of paramyotonic muscle reveals temperature-dependent Na and Cl channel defects that explain weakness and paralysis, though not paramyotonic stiffness.

Cite This Study

Lehmann‐Horn et al. (1981) studied this question.

synapsesocial.com/papers/6a7d4ea9c7e6f6a50737d3dfhttps://doi.org/10.1002/mus.880040508
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sodium currents in mammalian muscle1977 · 110 citations
  2. 2Cable parameters, sodium, potassium, chloride, and water content, and potassium efflux in isolated external intercostal muscle of normal volunteers and patients with myotonia congenita1971 · 158 citations
  3. 3Effects of potassium depletion and insulin on resting and stimulated skeletal rat muscle.1979 · 31 citations
  4. 4PARAMYOTONIA CONGEN1TA: AN ELECTROPHYSIOLOGICAL STUDY1972 · 10 citations