January 29, 2009Acta Neurologica Scandinavica
Skeletal muscle in paramyotonia congenita: biochemistry, histochemistry and morphology
Population
12 patients with paramyotonia congenita
Comparison
Percutaneous needle biopsies from the brachial… vs Healthy controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
Should not yet alter management of paramyotonia congenita; leaves open the clinical relevance of central nuclei for progression and targeted studies.
Structured PICO
P
Population
12 patients with paramyotonia congenita
I
Intervention
Percutaneous needle biopsies from the brachial biceps muscle
C
Comparator
Healthy controls
O
Outcome
Muscle fibre area, distribution of muscle fibre types I, II-A and II-B, capillarization, signs of myopathy, and biochemical markerssurrogate
Patients with paramyotonia congenita show signs of myopathy with central nuclei, but normal muscle fiber distribution, capillarization, and biochemical markers compared to healthy controls.
Cite This Study
Friis et al. (2009) studied this question.