Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats
Why the study?
Does exercise training reduce exercise pressor reflex overactivity in spontaneously hypertensive rats?
Population
28 rats: untrained normotensive Wistar-Kyoto rats, exercise-trained WKY, untrained spontaneously…
Comparison
3 months of wheel running (exercise training) vs Untrained (sedentary control)
Design
Preclinical
Follow-up
3 months
Authors
Discussion
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Member takes
Implication
May guide exercise interventions targeting pressor reflex overactivity in hypertension; leaves open clinical translation from rat models.
Structured PICO
Does exercise training reduce exercise pressor reflex overactivity in spontaneously hypertensive rats?
P
Population
28 rats: untrained normotensive Wistar-Kyoto rats (n=6), exercise-trained WKY (n=7), untrained spontaneously hypertensive rats (n=8), and exercise-trained SHR (n=7).
I
Intervention
3 months of wheel running (exercise training)
C
Comparator
Untrained (sedentary control)
O
Outcome
Changes in mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) in response to muscle contraction, passive muscle stretch, and hindlimb intra-arterial capsaicin administrationsurrogate
Exercise training significantly diminishes the abnormally exaggerated exercise pressor reflex function in spontaneously hypertensive rats.
Cite This Study
Mizuno et al. (2015) studied this question.