The main aim of the study is to develop and validate a simple and rapid liquid chromatographic analytical method for simultaneous determination of trace level of un‐sulfated alcohol impurities in sodium lauryl sulfate using high‐performance liquid chromatography with a refractive index detector. The chromatographic separation was achieved using flow rate of 3.0 ml/min with a Waters Symmetry C18 (150 × 4.6 mm, 5 μm) column and 50°C as a column temperature. The mobile phase comprised milliQ water and acetonitrile in the ratio of 30:70 v/v respectively. The detection was performed using a refractive index detector at a sensitivity of 64. The resolutions among n‐decanol, n‐dodecanol, n‐tetradecanol, n‐hexadecanol, and n‐heptadecanol were found to be >4. Regression analysis showed a correlation coefficient for the stated compounds of >0.999. The validated HPLC method was utilized effectively for the estimation of un‐sulfated alcohols in quality control labs for commercial release of sodium lauryl sulfate.
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Katakam et al. (2020) studied this question.
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