Key result
Autologous pericardial aortic valve reconstruction yields zero operative mortality and stable intermediate-term hemodynamics.
Why the study?
Autologous treated pericardium for aortic valve reconstruction has shown good results, prompting evaluation of its feasibility and benefits to avoid valve replacement complications and costs.
Observational (n=43)
No
Objective: Several authors have reported good results with the use of autologous treated pericardium for aortic valve reconstruction with good results specially the current series of Ozaki, so we decided to start our learning curve in this type of surgery for its benefits and to avoid the cost and potential complications that may be resulted from aortic valve replacement.Methods: Between August 2013 and November 2015, 43 patients were scheduled for aortic valve reconstruction using gluataraldehyde treated autologous pericardium.They were isolated aortic lesions or associated with repairable mitral or mitral and tricuspid valve lesion (26 patients were pure aortic regurge, 8 patients were aortic regurge + mild to moderate stenosis, 5 patients were aortic valve lesion associated with mitral regurge and 4 patients were aortic lesions associated with mitral and tricuspid regurge).Their mean age was 30.4 ± 6.7 and male/female was 25/18.We used Gaspayran formula to fabricate new pericardial leaflet, all patients were evaluated by transesophygeal echo before discharging from the operating room.Results: 4 patients out of 43 patients have undergone aortic valve replacement (2 of them because of mitral valve repair failed and the other 2 because of thickened pericardium and adhesion) aortic valve reconstruction was done successfully in the remaining patients (39 patients).There were no hospital deaths, transthoracic echo before discharge from the hospital revealed no regurge and no significant pressure gradient, also follow up echo for a mean period 21.5 ± 6.9 months revealed stable aortic valve function with no significant pressure gradient or significant regurge.Conclusion: Aortic valve reconstruction with treated autologous pericardium is feasible with acceptable hemodynamic.The cornerstone of this surgery is perfect sizing and fabricating the new pericardial aortic leaflets and precise suturing methods.
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Magdy Hassanein (2017) conducted an observational in Aortic Valve Insufficiency (n=43). Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium was evaluated on Hospital death and echocardiographic valve function (pressure gradient and regurgitation). Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium resulted in zero hospital deaths and stable valve function with no significant pressure gradient or regurgitation over a mean 21.5-month follow-up.
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