Aging‐Related Endothelial Progenitor Cell Dysfunction and Its Association with IL‐17 and IL‐23 in HFmrEF Patients

Figures

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  Figure 1. EPC function of younger and older patients. The adhesion (a), migration (b), and proliferation (c) of circulating EPCs decreased in older HFmrEF patients. Data were given as mean ± SD and compared with the Student's t-test. #P < 0.05vs. younger group.

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  Figure 2. Comparison of EPC function between the high MAGGIC score group and low-score group. The high MAGGIC score group had lower circulating EPC adhesion (a), migration (b), and proliferation (c) than the low-score group. Data were given as mean ± SD and compared with the Student's t-test. #P < 0.05vs. score < 25 group.

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  Figure 3. Relationship between MAGGIC score and EPC function. The MAGGIC score was negatively correlated with the circulating EPC adhesion (a), migration (b), and proliferation (c). Correlations of normally distributed data were analysed with Pearson's test, and nonnormally distributed data were analysed with Spearman's test.

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  Figure 4. Comparisons of IL-17 and IL-23 levels. IL-17(a) and IL-23 (b) were higher in older patients than in younger ones. Similarly, patients with MAGGIC score ≥ 25 had higher IL17 (c) and IL-23 (d) levels than those in the <25 score group. Data were given as mean ± SD and compared with the Student's t-test. #P < 0.05vs. younger group or < 25 score group.

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  Figure 5. Relationships between proinflammatory cytokines and MAGGIC score or EPC function. MAGGIC score was positively correlated with IL-17 (a) and IL-23 (E). EPC adhesion, migration, and proliferation were negatively related to IL-17 (b)–(d) and IL-23 (f)–(h). Correlations of normally distributed data were analysed with Pearson's test, and nonnormally distributed data were analysed with Spearman's test.

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  Figure 6. Relationships between age and the MAGGIC score, inflammatory cytokines, or EPC function. Positive relationships were observed between age and the MAGGIC score (a), IL-17 (b), and IL-23 (c), but negative correlations were found between age and EPC adhesion (d), migration (e), and proliferation (f). Correlations of normally distributed data were analysed with Pearson's test, and nonnormally distributed data were analysed with Spearman's test.