Describes a reproducible technique for inducing standardized functional coronary artery stenosis in acute animal experiments.
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Enables standardized acute coronary stenosis models in animals; leaves open translation to clinical research.
A simple technique to induce a reproducible functional stenosis of a coronary artery in acute experiments is described. The artery is narrowed by stepwise twisting of a thin copper wire until a zero flow occlusion of 10 sec is no longer followed by a period of diastolic reactive hyperemia. The degree of coronary stenosis is expressed as the diastolic hemodynamic resistance over the copper wire. This technique allows comparison from animal to animal and carries the possibility to follow changes in myocardial metabolism at a given degree of coronary stenosis.
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Meer et al. (2008) studied this question.
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