December 1, 2003AJP Heart and Circulatory Physiology
Chronic coronary artery stenosis induces impaired function of remote myocardium: MRI and spectroscopy study in rat
Key result
Induction of coronary artery stenosis in rats significantly reduced segmental wall thickening in the ischemic region (9% vs 75% in controls; P<0.05) and impaired remote myocardial function.
Why the study?
Does chronic coronary artery stenosis induce functional and metabolic changes in remote myocardium in a rat model?
Population
Wistar rats
Comparison
Induction of chronic coronary artery stenosis vs Control rats without stenosis
Design
Preclinical
Follow-up
2 weeks
Authors
Discussion
Loading...
Member takes
Implication
Animal data support remote myocardial effects in coronary stenosis; leaves open translation to human chronic coronary syndromes.
Structured PICO
Does chronic coronary artery stenosis induce functional and metabolic changes in remote myocardium in a rat model?
P
Population
18 Wistar rats (11 with induced coronary stenosis and 7 controls) evaluated 2 weeks post-induction for morphological, functional, and metabolic changes.
I
Intervention
Induction of chronic coronary artery stenosis
C
Comparator
Control rats without stenosis
O
Outcome
Morphological, functional, and metabolic changes (segmental wall thickening, global heart function, perfusion, PCr/ATP ratio) assessed by MRI and spectroscopysurrogate
Main Result
Absolute Event Rate: 9% vs 75%
p-value: p=< 0.05
Chronic coronary stenosis in a rat model impairs both function and energy metabolism not only in the ischemic region but also in the remote myocardium, which can be simultaneously assessed using fused MRI and spectroscopy.
Cite This Study
Nahrendorf et al. (2003) studied chronic coronary artery stenosis (n=18). Induction of coronary artery stenosis vs. Control (no stenosis) was evaluated on segmental wall thickening (p=< 0.05). Induction of coronary artery stenosis in rats significantly reduced segmental wall thickening in the ischemic region (9% vs 75% in controls; P<0.05) and impaired remote myocardial function.