What question did this study set out to answer?

To evaluate the feasibility of combining first-pass contrast-enhanced MRI and myocardial tagging to noninvasively measure regional blood flow and 2D myocardial deformation during moderate coronary stenosis.

May 1, 1996Magnetic Resonance in Medicine

Myocardial perfusion and function in dogs with moderate coronary stenosis

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Authors

DKDara L. KraitchmanJohns Hopkins University NWNorbert WilkeUniversity of North Florida EHE. HEXEBERGUniversity of Minnesota

Discussion

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Implication

Preclinical study demonstrates stress-induced hypoperfusion and impaired regional shortening during coronary stenosis in dogs, indicating the feasibility of combined functional MRI.

Key Points

To evaluate the feasibility of combining first-pass contrast-enhanced MRI and myocardial tagging to noninvasively measure regional blood flow and 2D myocardial deformation during moderate coronary stenosis.
Evaluated instrumented closed-chest canine models across three conditions: baseline control, moderate coronary stenosis via partial left anterior descending (LAD) artery occlusion, and moderate stenosis with dobutamine stress.
Acquired first-pass contrast-enhanced images using polylysine-Gd-DTPA and assessed 2D myocardial deformation using spatial modulation of magnetization (SPAMM) tagging, with MRI blood flow validated using radiolabeled microspheres.
Significant anterior-to-posterior hypoperfusion emerged only during dobutamine loading on contrast-enhanced MRI (ratio: control = 1.077 ± 0.15 vs. stenosis with dobutamine = 0.477 ± 0.11; P < 0.03), matching radiolabeled microsphere measurements (1.18 ± 0.2 vs. 0.44 ± 0.1 ml/min/g; P < 0.002).
Significant regional shortening deficits were confined to the dobutamine-stressed state (P < 0.02), where the ischemic anterior region exhibited impaired shortening (P = NS) while the unaffected posterior wall exhibited increased shortening compared to baseline (control = 0.964 ± 0.02 vs. stenosis with dobutamine = 0.884 ± 0.03; P < 0.001).

Cite This Study

Kraitchman et al. (1996) studied this question.

synapsesocial.com/papers/6a701f6178a11c550e09f049 https://doi.org/10.1002/mrm.1910350519

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Implication

Preclinical study demonstrates stress-induced hypoperfusion and impaired regional shortening during coronary stenosis in dogs, indicating the feasibility of combined functional MRI.

Myocardial perfusion and function in dogs with moderate coronary stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Myocardial perfusion and function in dogs with moderate coronary stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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