Why the study?
Does insulin or tolbutamide treatment reverse the altered conversion of arachidonic acid to prostacyclin and thromboxane in streptozotocin-induced diabetic rats?
Does insulin or tolbutamide treatment reverse the altered conversion of arachidonic acid to prostacyclin and thromboxane in streptozotocin-induced diabetic rats?
Glycemic control with insulin or tolbutamide partially reverses the pro-thrombotic alterations in arachidonic acid metabolism seen in experimental diabetes.
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Glycemic control may normalize prostanoid balance in experimental diabetes; leaves open any effect on human thrombotic risk.
Valentovic et al. (1983) studied this question.
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