Answers are grounded in this paper and cite their sources.
The isolated rat heart is perfused with adenosine-8-C14, or a mixture of ATP-8-C14 and ATP-γ-P32 of known isotope (C14/P32) ratio. The results indicate that any difference between the rate of incorporation of adenosine-C14 or ATP-C14 into myocardial nucleosides and nucleotides fraction did not show significance, and also that any difference of the C14 distribution in the perfusates between adenosine-C14 and ATP-C14 perfused by the isolated rat hearts did not show singnificance.When perfused with C14-and P32-ATP of known isotope ratio, ATP isolated from the myocardium showed an isotope ratio (C14/P32) approximately 5 times greater than that of ATP in perfusion fluid.These results suggest that ATP might be first degraded and later resynthesized intracellularly.
No takes yet. Share an insight, caveat, or question.
HATTORI et al. (1969) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: