Why the study?
Does intracoronary injection of iodixanol improve hemodynamic tolerability compared to iohexol and ioxaglate during coronary arteriography in dogs with and without acute left ventricular failure?
Population
Anesthetised dogs, both with and without left ventricular failure induced by microembolization of the area…
Comparison
Intracoronary injection of 6 ml iodixanol 320 mg… vs Iohexol and ioxaglate
Design
Preclinical
Authors
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Iodixanol may be preferable in acute LV failure models; leaves open translation to human coronary arteriography.
Does intracoronary injection of iodixanol improve hemodynamic tolerability compared to iohexol and ioxaglate during coronary arteriography in dogs with and without acute left ventricular failure?
In a canine model, iodixanol induced minimal hemodynamic changes during coronary arteriography compared to other contrast media, suggesting it is well tolerated even in acute ischemic heart failure.
Kløw et al. (1991) studied this question.
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