Key result
Ioxaglate prolongs QT interval during coronary angiography compared to sodium-free iohexol.
Why the study?
It has been suggested that sodium addition to low osmolality contrast media may reduce ventricular fibrillation and conduction disturbances during coronary angiography.
Population
30 patients undergoing coronary angiography
Comparison
Ioxaglate (with sodium) vs iohexol (without sodium)
Design
Randomized double-blind study
Follow-up
120 seconds
Authors
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Ioxaglate prolongs QT/AH intervals versus iohexol; challenges sodium addition as primary safeguard against conduction disturbances in angiography.
RCT (n=30)
Double-blind
Randomized
p-value: p=<0.01
Vik‐Mo et al. (1990) conducted an RCT in Coronary angiography (n=30). Ioxaglate (with sodium) vs. Iohexol (without sodium) was evaluated on Electrophysiological and hemodynamic effects (QT interval, AH-interval, systolic blood pressure, heart rate) (p=<0.01). Ioxaglate (with sodium) significantly prolonged the QT interval at 10 seconds (P<0.01) and 120 seconds (P<0.05) during coronary angiography, whereas iohexol (without sodium) did not.
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