Stunned Myocardium in the Toxic Shock Syndrome

Brief Reports1 December 1992Stunned Myocardium in the Toxic Shock SyndromeJennie R. Crews, MD, J. Kevin Harrison, MD, G. Ralph Corey, MD, Charles Steenbergen, MD, PhD, Thomas M. Bashore, MDJennie R. Crews, MDSearch for more papers by this author, J. Kevin Harrison, MDSearch for more papers by this author, G. Ralph Corey, MDSearch for more papers by this author, Charles Steenbergen, MD, PhDSearch for more papers by this author, Thomas M. Bashore, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-11-912 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough it is not commonly recognized, myocardial dysfunction in the toxic shock syndrome may be severe, even life-threatening (1, 2). The cause of this acute cardiomyopathy remains unclear. Clinically, left ventricular dysfunction in the toxic shock syndrome has been reversible, similar to prolonged but transient postischemic myocardial dysfunction, a process termed "stunned myocardium" (3). Cardiac histopathologic findings in the toxic shock syndrome are limited to autopsy data, and the pathologic changes seen have been modest compared with the clinical severity of left ventricular dysfunction (4, 5). We report the first premortem cardiac histologic findings in a patient with severe, acute...References1. FisherHorowitzAlbertson CZT. Cardiorespiratory failure in toxic shock syndrome: effect of dobutamine. Crit Care Med. 1985;13:160-5. CrossrefMedlineGoogle Scholar2. Chesney P. Clinical aspects and spectrum of illness of toxic shock syndrome: overview. Rev Infect Dis. 1989;2:S1-7. CrossrefGoogle Scholar3. KlonerPrzyklenkPatel RKB. Altered myocardial states. The stunned and hibernating myocardium. Am J Med. 1989;86:14-22. CrossrefMedlineGoogle Scholar4. ParisHerwaldtBlumSchmidShandsBroome ALDGKC. Pathologic findings in twelve fatal cases of toxic shock syndrome. Ann Intern Med. 1982;96:852-7. LinkGoogle Scholar5. LarkinWilliamsOsterholmToftePosalaky SDMRZ. Toxic shock syndrome: clinical, laboratory, and pathologic findings in nine fatal cases. Ann Intern Med. 1982;96:858-64. LinkGoogle Scholar6. OlsonStevensMelish RDM. Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria. Rev Infect Dis. 1989;2:S313-5. CrossrefGoogle Scholar7. StevensTroyerMerrickMittenOlson DBDJR. Lethal effects and cardiovascular effects of purified alpha- and theta-toxins from Clostridium perfringens. J Infect Dis. 1988;157:272-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Duke University Medical Center, Durham, North Carolina. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUpdate on the COVID‐19‐associated inflammatory syndrome in children and adolescents; paediatric inflammatory multisystem syndrome‐temporally associated with SARS‐CoV‐2Analysis on sarcoglycans expression as markers of septic cardiomyopathy in sepsis-related deathSuccessful Use of Extracorporeal Membrane Oxygenation in an Adult Patient With Toxic Shock-Induced Heart FailureA case of toxic shock syndrome with ST-segment elevation during follow-upTOXIC SHOCK SYNDROMECan patient decision aids help people make good decisions about participating in clinical trials? A study protocolToxic Shock SyndromeReversible myocardial dysfunction in critically ill, noncardiac patients: A review*Myocardial Stunning Following Respiratory ArrestSeptic cardiomyopathy as a cause of long QT syndromeAmphotericin B-induced dilated cardiomyopathy 1 December 1992Volume 117, Issue 11Page: 912-913KeywordsAutopsyCardiomyopathiesMuscular dystrophiesMyocardiumToxic shock syndrome Issue Published: 1 December 1992 PDF DownloadLoading ...