Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K + channels
Population
Heterologous systems expressing G-protein gated inward rectifier K+ channels (GIRK)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
These animal data warrant no clinical changes; leaves open RGS4 as a modulator of human GIRK signaling.
Structured PICO
P
Population
Heterologous systems expressing G-protein gated inward rectifier K+ channels (GIRK)
I
Intervention
Nonhydrolyzable GTP analogues and RGS4
O
Outcome
Acute desensitization of receptor-activated GIRK currentssurrogate
The study reveals that the nucleotide exchange and hydrolysis cycle of G proteins drives the acute desensitization of GIRK channels, with RGS4 acting as a positive regulator of this process.
Cite This Study
Chuang et al. (1998) studied this question.