Why the study?
Does chronic, mild elevation of PKC activity improve postischemic recovery in adult mouse hearts?
Population
Isolated hearts from adult transgenic mice expressing a low level of activated PKCbeta throughout adulthood…
Comparison
Transgenic expression of activated PKCbeta vs Control hearts (non-transgenic)
Design
Preclinical
Authors
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Hypothesis-generating for PKC modulation in ischemia protection; leaves open translation from mouse models to human hearts.
Does chronic, mild elevation of PKC activity improve postischemic recovery in adult mouse hearts?
Long-term modest increase in PKC activity in adult mouse hearts improves postischemic recovery of contractile function without altering baseline function or high-energy phosphate levels.
Tian et al. (1999) studied this question.
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