Why the study?
Does myocyte-specific inhibition of PKCalpha enhance cardiac contractility and protect against infarction-induced heart failure in mice?
Population
Cardiac myocyte-specific transgenic mice with tetracycline-inducible dominant negative PKCalpha expression…
Comparison
Myocyte autonomous inhibition of PKCalpha vs Control mice
Design
Preclinical
Authors
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PKCα inhibition may enhance post-MI contractility in mice; leaves open translation to human HF therapy.
Does myocyte-specific inhibition of PKCalpha enhance cardiac contractility and protect against infarction-induced heart failure in mice?
Myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against heart failure following myocardial infarction in a mouse model.
Hambleton et al. (2007) studied this question.
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