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Chances of malignant transformation of nevus-cell nevi are greater in certain body areas than in others. Danger signals include change in color, size, shape or consistency, diffusion of pigment into adjacent skin, satellite nodules, and lymphadenopathy. Malignant melanoma resulting in metastases and death is rare prior to puberty. “Benign juvenile melanoma” conveys more clearly the expected course of a clinically benign type of compound nevus.Outstanding features of circumscribed precancerous melanosis are changeability, irregular outline, and uneven color. A tumor histologically identical to malignant melanoma often develops in such pigmented precancerous plaques.
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Sulzberger et al. (1959) studied this question.
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